Referring to a particular situation, thumbs up is positive; thumbs down is negative Also, click to see other meanings of this dream.Thumb 1. Direction, or direction in life. 2. Indicator of life or death (as in gladiator games). 3. Mobility.Thumb 1. Dexterity, ability to “handle” things. 2. Success (large thumb). 3. Dependence on others for mobility (as in “hitching a ride”). 4. Direction in life.